Vascular & Interventional Specialists

What Are the "Six Ps" of an Acute Arterial Occlusion?

Apr 10, 2024
What Are the "Six Ps" of an Acute Arterial Occlusion?

Acute arterial occlusion is a medical emergency, but do you know the signs? Learn how the “Six Ps” — pallor, pain, paresthesia, paralysis, pulselessness, and poikilothermia — can help you recognize this condition.

When it comes to medical emergencies, every second counts. Most people know that conditions like heart attack and stroke warrant immediate medical care. However, these aren’t the only medical emergencies, and being prepared is important.

Acute arterial occlusion is a vascular medical emergency that can cause limb loss or death. Fortunately, recognizing the signs and symptoms can make all the difference in avoiding these catastrophic consequences.

Because acute arterial occlusion is lesser known, the Six Ps — pallor, pain, paresthesia, paralysis, pulselessness, and poikilothermia — can help you identify the condition so you can get the treatment you need. Here’s what you need to know from our Vascular & Interventional Specialists team in Miami, Florida.

Understanding acute arterial occlusion

Acute arterial occlusion happens when a sudden blockage in an artery stops blood flow. This blockage may be caused by a blood clot, embolism, or severe arterial narrowing due to conditions like atherosclerosis.

When blood flow inside an artery stops, downstream tissues don’t get the oxygen. Acute arterial occlusion can lead to tissue ischemia, injury, and, ultimately, tissue death.

Tissue death is a significant complication that can cause limb loss or death without prompt care. Because of these risks, acute arterial occlusion is considered a vascular emergency.

The Six Ps: a guide to spotting acute arterial occlusion

Recognizing you need help is essential if you’re experiencing a medical emergency. The “Six Ps” are a simple mnemonic device for remembering the symptoms of acute arterial occlusion.

1. Pallor

Pallor means that the affected limb becomes unusually pale. When blood flow stops, reduced oxygen causes the skin to lose its normal, healthy coloration. For example, acute arterial occlusion in a leg artery can make that leg look notably paler compared to the other leg.

2. Pain

Pain is a hallmark symptom of acute arterial occlusion, often described as sudden and severe. The pain may be constant or intermittent, but it’s almost always intense and out of proportion to any apparent injury or trauma.

3. Paresthesia

Paresthesia is abnormal sensations like tingling, numbness, or pins and needles. As blood flow diminishes in the affected limb, nerves may become deprived of oxygen and alter your sensory perception. Sometimes, acute arterial occlusion can cause a loss of feeling altogether.

4. Paralysis

Paralysis is the loss of voluntary movement in the affected limb. It often starts as weakness or clumsiness, but as arterial occlusion progresses and tissue ischemia worsens, motor function continues to deteriorate. Paralysis indicates severe ischemic injury and warrants immediate medical intervention.

5. Pulselessness

Normally, arterial pulses can be felt throughout the body. However, in the case of acute arterial occlusion, the affected limb may lack a detectable pulse due to obstructed blood flow. Pulselessness is a critical sign indicating complete or near-complete arterial occlusion.

6. Poikilothermia

Poikilothermia is the medical term for a temperature decrease in the affected limb. As blood flow stops, the limb may feel noticeably cooler to the touch compared to other parts of the body. This temperature difference is a result of reduced metabolic activity in the tissues and impaired thermoregulation from a lack of blood flow.

Acute arterial occlusion is a medical emergency. If you or a loved one is experiencing any of the Six Ps of acute arterial occlusion, seek immediate care at your nearest emergency room or call 911.


By learning to recognize the signs and symptoms, you can do your part to potentially save limbs and lives. Learn more about acute arterial occlusion and treatment options with an appointment at Vascular & Interventional Specialists. Schedule online or call our Miami, Florida, office at 305-230-4664 today.